Tripterygium wilfordii has many effects, such as clearing heat and detoxicating, expelling wind and clearing collaterals, relaxing tendons and activating blood circulation, and has certain curative effects on rheumatoid arthritis, nephritis, lupus erythematosus and other diseases.
The main active components of Tripterygium wilfordii are triptolide, tripterygium glycoside, triptolide, etc.
It is reported that Tripterygium wilfordii preparation has certain reproductive toxicity, and the damage to the reproductive system of male rats is mainly manifested by the increase in the number of sperm with abnormal morphology, and the decrease of sperm motility and vitality; High-dose or long-term use of drugs will also cause testicular spermatogenic cells to fall off, reduce or even disappear, thus affecting the occurrence of sperm; Decreases the activities of testicular acid phosphatase (ACP), hyaluronidase (HASe), succinate dehydrogenase (SDH) and phosphofructose kinase 1 (PFK1) and other related enzymes; Inhibit the key enzymes required for the synthesis of inhibin B (INHB) and testosterone, thus producing reproductive toxicity to male rats.
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